DRUG INTERACTION GUIDE

Coenzyme
Q10

If you're already using a prescription drug to treat your problem, check its compatibility and interactions with our range of natural products here.

	A safe and usually beneficial combination/interaction.
	Observe. Small likelihood of an interaction. Watch for negative effects.
	Caution. Some chance of a negative interaction. Combination could be dangerous in some circumstance.
	Avoid. This combination is likely to be dangerous. Sometimes this risk can be lessened if used under medical supervision or if the doses or timing of doses are adjusted.

Drug	Interaction	Action Required
Beta-Blockers (Acebutolol Hydrochloride, Sectral, Atenolol, Tenormin, Alprenolol, Betaxolol Hydrochloride, Kerlone, Bisoprolol Fumarate, Zebeta, Carteolol, Cartrol, Carvedilol, Coreg, Esmolol Hydrochloride, Brevibloc, Labetalol Hydrochloride, Normodyne, Trandate, Metoprolol Lopressor, Toprol XL, Nadolol, Corgard, Penbutolol, Levatol, Pindolol, Visken, Propranolol Hydrochloride, Betachron E-R, Inderal, Inderal LA, Sotalol, Betapace, Timolol Maleate, Blocadren)	Beta-Blockers may impair the body's ability to utilize Coenzyme Q10. This is particularly worrisome, because Coenzyme Q10 plays a significant role in normal heart function. Depletion of Coenzyme Q10 might be responsible for some of the side effects of Beta-Blockers. In one study, Coenzyme Q10 supplements reduced side effects caused by Beta-Blockers propranolol. Timolol may interfere with Coenzyme Q10 production to a lesser extent than other Beta-Blockers.	This combination is safe (and desirable). Coenzyme Q10 is an important nutrient and Beta-Blockers-induced interference with Coenzyme Q10 is not desirable. Coenzyme Q10 supplementation may counteract this depletion.
Doxorubicin (Adriamycin)	Pretreatment with Coenzyme Q10 prior to Doxorubicin therapy counteracts the toxic effects of Doxorubicin on the heart.	This combination is safe (and desirable). The recommended dosage of Coenzyme Q10 for reducing Doxorubicin toxicity is 100 mg per day.
Thiazides (a class of Diuretics used to lower blood pressure - includes Aquatensen, Bendroflumethiazide, Benzthiazide, Chlorthiazide, Chlorthalidone, Diucardin, Diurese, Diurigen, Diuril, Enduron, Exna, Hydrochlorthiazide, Hydromox, Hygroton, Indapamide, Lozol, Metahydrin, Methylchlorthiazide, Methyclothiazide, Metolozone, Mykroz, Naqua, Naturetin, Polythiazide, Renese, Quinethazone, Saluron, Thalitone, Trichlormethiazide, Zaroxolyn)	Thiazides may impair the body's ability to synthesize Coenzyme Q10, a substance important for normal heart function.	This combination is safe (and desirable).
Tricyclic Antidepressants (Amitriptyline Hydrochloride, Elavil, Amoxapine, Asendin, Clomipramine Hydrochloride, Anafranil, Desipramine Hydrochloride, Norpramin, Doxepin Hydrochloride, Sinequan, Imipramine Tofranil, Nortriptyline Hydrochloride, Aventyl, Pamelor Protriptyline Hydrochloride, Vivactil, Trimipramine Maleate, Surmontil)	Preliminary evidence suggests that Tricyclic Antidepressants might deplete the body of coenzyme Q10. Based on this observation, it has been suggested (but not proved) that coenzyme Q10 supplementation might help to prevent the heart-related side effects that can occur with the use of Tricyclic Antidepressants.	This combination is safe (and desirable).